I am the mother of a four year old boy with CF, I don't have CF but I took prednisone for a digestive disease. I was off and on it for about ten years--My highest dose was 60mg every day. It did wonders for controlling inflammation in my digestive tract, however the side effects were miserable. My face swelled up, I got stretch marks from the rapid water weight gain, I had insomnia, mood swings, migraines, etc... The long term side effects are still bothering me, even though I stopped taking the medicine over ten years ago. I am 27 and have the bone density of a woman in her 60's, I have glaucoma, high-blood pressure, my gallbladder was removed because of gallstones, My periods are very irregular. THese are all some of thr potential long term effects of prednisone that will continue to plague me. I am not a doctor and so I can't advise you not to take prednisone, but you should definitly be aware of the risks.